Biophotonic Imaging: Early Disease Detection and Guidance

Modern healthcare strives to provide early-stage cancer screening to mitigate cancer incidence and mortality worldwide. The gold standard histopathological evaluation of resected tissue (biopsy) is inherently invasive and time-consuming. Instead, optical biopsy could assist pathologists in early cancer screening by exploiting the phenomena of light-tissue interactions with excellent optical sectioning capabilities, potentially circumventing tissue resection. A combination of different noninvasive or minimally invasive imaging modalities is the key to retrieving morphological and biochemical attributes of biological tissue.

Multi-photon light-sheet fluorescence microscopy (MP-LSFM) and its endoscopic implementation could serve as a powerful imaging tool for fast volumetric data acquisition from tissue with subcellular spatial resolution as well as reduced phototoxicity.

While MP-LSFM provides metabolic information from tissue in vivo, optical coherence tomography (OCT) can provide its morphological information and extract optical properties. Such a multimodal endoscope could improve sensitivity and specificity and reduce unwanted excisional biopsies.

In this webinar, Dr. Andersen will talk about the development of a multimodal imaging endoscope for colorectal cancer screening. He will also describe the novel spatial-offset OCT technique that makes use of multiple scattered photons to collect information at unprecedented depths even from hard tissue.

Subject Matter Level: Intermediate - Assumes basic knowledge of the topic

What You Will Learn:
• Design considerations for optical systems for early stage cancer screening.
• Application of multiphoton microscopy, lightsheet microscopy, OCT, etc. and their combination in disease diagnostics.

Who Should Attend:
• Students with biomedical engineering or biomedical optics background
• Researchers working with biomedical optical imaging and/or their clinical translation

About the Presenter: Peter Eskil Anderson from The Department of Health Technology, Technical University of Denmark

Peter E. Andersen has more than 20 years of experience in research and development of biophotonic imaging modalities, light sources for biomedical optics, including developing OCT systems, and nonlinear microscopy. He leads the activities within biomedical optics at DTU Health Tech, and in addition, he is Head of the DTU Health Tech Graduate School (~160 PhD students). He has published more than 150 papers on lasers, imaging systems and their bio-applications and holds several patents. He is editorial board member of Journal of Biomedical Optics and Journal of Biophotonics. He is co-founder of the International Summer School Biophotonics, see www.biop.dk. He is co-founder and ex officio board member of the company Norlase ApS, Denmark. He is Fellow of OSA (2015) and Fellow of SPIE (2015).