Microscopy Histopathology and Analytics
Events
Microscopy Histopathology and Analytics
24 April 2022 – 27 April 2022 The Westin Fort Lauderdale Beach Resort, Fort Lauderdale, Florida United States
Example topics central to this meeting are novel forms of microscopy, computational modeling and algorithms, novel contrast agents, and clinical analytics. Example application areas are clinical diagnostics/prognostics and decision support, surgical and non-surgical therapy guidance, high-throughput drug screening, and biomarker evaluation.
Essential Links
Biophotonics Congress: Biomedical Optics
Topics
1. Novel Technology, Devices, Methods, and Models
- Miniaturized devices
- Endoscopic devices
- Volumetric, hyperspectral, and time-resolved microscopies
- Mobile phone-based microscopy
- Multimodal microscopy
- Multispectral microscopy
- Computational microscopy
- Label-free imaging and spectroscopy
2. Computational Tools and Algorithms
- Image denoising, restoration, and resolution enhancement
- Image segmentation and tracking (2D, 3D, and 4D)
- Image translation (e.g., Generative Adversarial Networks (GANs))
- Smart microscopy methods (e.g. closed-loop alignment)
- Fusion of multi-modal data
- Diagnostic, prognostic, and predictive classification
- Data visualization/rendering, annotation, and augmentation
- Handling large and multi-dimensional data (e.g. compression, cloud computing)
- FAIR data and analysis solutions
- User-friendly open-source tools
3. Molecular Microscopy and Tissue Preparation
- Quantitative approaches for pathology
- Advances in devices and methods
- Novel contrast agents, reporters, probes, molecules
- Probe delivery and labeling methods
- Optical clearing, tissue expansion
- In situ hybridization, spatial transcriptomics, preservation of nucleic acids
- Optical microscopy of organoids and engineered tissues
4. Clinical Biophotonics
- Bedside imaging
- In vivo microscopy
- Ex vivo digital/computational pathology
Speakers
- Mihaela Balu, UC Irvine Beckman Laser Institute, United States
Fast, Large Area Multiphoton Exoscope (FLAME) for Clinical Skin Imaging - Margarida Barroso, Albany Medical College, United States
The Role of 3D Cancer Cell Growth in Organelle Morphology, Topology and Function - Arnaud Dubois, Institut d'Optique Graduate School, France
Optical Skin Biopsy with Line-field Confocal Optical Coherence Tomography (LC-OCT) - Nicholas Durr, Johns Hopkins University, United States
Non-invasive Blood Analysis with Deep Learning and Oblique Back-illumination Microscopy - Roarke Horstmeyer, Duke University, United States
Parallelized Microscopy for Teravoxel Whole-slide Imaging - Jennifer Hunter, University of Rochester, United States
Adaptive Optics Two-photon Excited Fluorescence Lifetime Ophthalmosopy - Michael Jenkins, Case Western Reserve University, United States
New Methods and Tools for 3D Microscopy - Lija Joseph, Lowell General Hospital, United States
Cytological Detection of Thyroid Cancer - DongKyun Kang, University of Arizona, United States
Low-cost, In Vivo Confocal Microscopy - Muyinatu Lediju Bell, Johns Hopkins University, United States
Laser Safety for Photoacoustic-guided Surgery - Faisal Mahmood, Harvard University, United States
Data-efficient and Multimodal Computational Pathology - Shachi Mittal, University of Washington, United States
Digital and Molecular Profiling of Breast Cancer - Chetan Patil, Temple University, United States
Monte-Carlo-based Simulations of Sources of Bias in Clinical Measurements - Nicholas Reder, Lightspeed Microscopy, United States
3D Pathology with AI for Improved Drug Development and Clinical Diagnostics - Zachary Smith, Univ of Science and Technology of China, China
Enabling Cost-effective, Precise Blood Analysis Through Illumination and Pupil Engineering - Martin Villiger, Wellman Center for Photomedicine, United States
Catheter-based Optical Coherence Polarimetry for Guiding Interventions
Committee
- Jonathan Liu, Univ. of Washington, USA, General Chair
- Anna Yaroslavsky, Harvard Univ., USA, General Chair
- Nada Boustany, Rutgers Univ., USA, Program Chair
- Florian Jug, Fondazione Human Technopole, Italy, Program Chair
- Eric Tkaczyk, Vanderbilt Univ. Medical Center, USA, Program Chair
- Charles DiMarzo, Northeastern University, USA
- Irene Georgakoudi, Tufts University, USA
- Lida Hariri, Massachusetts General Hospital, USA
- Xavier Intes, Rensselaer Polytechnic Institute, USA
- Richard Levenson, University of California at Davis, USA
- Yang Liu, University of Pittsburgh, USA
- Milind Rajadhyaksha, Memorial Sloan-Kettering Cancer Center, USA
- Francisco "Paco" Robles, Georgia Institute of Technology, USA
- Inga Saknite, University of Latvia, Latvia
- Yoav Shechtman, Technion - Israel Institute of Technology, Israel
- Kevin Tsia, University of Hong Kong, Hong Kong
Plenary Session
Laura Marcu
University of California, Davis, USA
Bringing Cancer to Light in the Operating Room
This presentation concerns the development for clinically-compatible multispectral fluorescence lifetime imaging (FLIM) techniques and applications in surgical oncology. We will show FLIM’s potential for real-time intraoperative delineation of brain tumors and head-and-neck cancer during robotic surgery.
About the Speaker
Laura Marcu is Professor of Biomedical Engineering and Neurological Surgery at the University of California at Davis. She received her Ph.D. in biomedical engineering (1998) from the University of Southern California, Los Angeles. Since 2007, she has served also as co-director of the Comprehensive Cancer Center - Biomedical Technology Program at the UC Davis Medical Center. Her research interest is in the area of biomedical optics, with a particular focus on research for the development of label-free optical spectroscopy and imaging techniques for tissue diagnostics and image-guided interventions. Area of applications include surgical oncology, intravascular cardiovascular diagnostics, and regenerative medicine. She is an elected Fellow of AAAS, AIMBE, BMES, Optica, SPIE and NAI.
Wolfgang Drexler
Medical University Vienna, Austria
OCT in its 30's
After three decades, more than 75,000 publications and numerous companies being involved in its commercialization, this talk focuses on disruptive forward-looking innovations and key-technologies to further boost OCT performance enabling significantly enhanced medical diagnosis.
About the Speaker
Wolfgang Drexler, PhD, is a Professor of Medical Physics and the Head of the Center for Medical Physics and Biomedical Engineering at the Medical University of Vienna, Vienna, Austria. He spent 2 years at the Massachusetts Institute of Technology, Cambridge, MA, USA. Prior to his current position, Dr. Drexler was a Professor of Biomedical Imaging at Cardiff University, Wales, UK. Dr. Drexler’s main research area is the establishment of a novel generation of optical imaging platforms with the potential to revolutionise fundamental biological research as well as medical diagnosis. Dr. Drexler has authored >190 peer-reviewed publications and >600 conference proceedings or abstracts. He is or has previously held positions as editor or co-editor of 12 books, including 2 editions of Optical Coherence Tomography: Technology and Applications. In addition, he has given >250 invited or keynote presentations since 2000 and accomplished € 16 million research grant income since 2000.
Daniel Razansky
ETH Zürich, Switzerland
Citius, altius, fortius – boosting speed, resolution, and depth in fluorescence and optoacoustic imaging
The talk focuses on the latest additions to the arsenal of fluorescence and optoacoustic techniques to enable noninvasive deep tissue imaging of rapid biological dynamics at multiple scales, from single cells to whole organisms.
About the Speaker
Daniel Razansky is Full Professor of Biomedical Imaging with double appointment at the Faculty of Medicine, University of Zurich and the Department of Information Technologies and Electrical Engineering of ETH Zurich, where he also serves as Director of the joint Preclinical Imaging Center. He earned PhD in Biomedical Engineering (2006) and MSc in Electrical Engineering (2001) from the Technion - Israel Institute of Technology and did postdoctoral research at the Center for Molecular Imaging Research of the Harvard Medical School in Boston. Prior to moving to Zurich in 2019, he was Professor of Molecular Imaging Engineering at the Technical University of Munich and Helmholtz Center Munich. His Lab pioneered a number of imaging technologies for pre-clinical research and clinical diagnostics successfully commercialized worldwide, among them the multi-spectral optoacoustic tomography (MSOT) and hybrid optoacoustic ultrasound (OPUS). Razansky’s research has been recognized by the German Innovation Prize and multiple awards from the ERC, NIH, SNF, DFG and HFSP. He is a Founding Editor of the Photoacoustics journal and serves on Editorial Boards of a number of journals published by Springer-Nature, Elsevier, IEEE and AAPM. He is also an elected Council Member of the European Society for Molecular Imaging (ESMI), serves on the IEEE Technical Committee on Biomedical Imaging and Image Processing and has chaired numerous international conferences of the Optica (formerly OSA), WMIS, IEEE, ESMI and IFMBE. He is also an elected Fellow of the Optica (formerly OSA) and SPIE.
Anita Mahadevan-Jansen
Vanderbilt University, USA
Near infrared autofluorescence and other label free optical techniques for intraoperative guidance of endocrine surgery
In this presentation, the development of label free spectroscopy and imaging methods including near infrared autofluorescence for the identification of the parathyroid gland and evaluating its perfusion state during thyroidectomies and parathyroidectomies will be presented. We will also discuss other ways in which optical spectroscopy and imaging can help the endocrine surgeon in patient care.
About the Speaker
Anita Mahadevan-Jansen is a Professor of Biomedical Engineering and holds the Orrin H. Ingram Chair in Biomedical Engineering at Vanderbilt University. Her research considers the development of optical techniques for clinical diagnosis and surgical guidance, particularly using Raman and fluorescence spectroscopy. She serves on the Board of Directors of SPIE, and is a Fellow of SPIE, Optica, Society for Applied Spectroscopy, and the American Society for Lasers in Medicine and Surgery. She is currently serving as SPIE's President in 2022.
Special Events
Women of Biophotonics Meet & Greet
Saturday, 23 April 19:00 – 20:00
Please join Chairs Christine P. Hendon, Rainer A. Leitgeb and other members of the Biophotonics Congress committee for an informal networking event bringing together the women in biomedical optics. The program's goal is to provide an opportunity to meet other women in the field and discuss challenges and opportunities for women in biophotonics. All are welcome, regardless of gender, so please join us to meet others attending this cutting-edge conference and share your ideas on helping ensure our community and this meeting is as welcoming and inclusive as possible.
The Physicians' Perspective: A Joint MHA and Translational Session
Sunday, 24 April 13:30 – 15:30
13:30-14:00: Optical Skin Biopsy with Line-field Confocal Optical Coherence Tomography (LC-OCT), Arnaud Dubois, Damae Medical, France
14:00-15:30: Panel Discussion: Clinicians' Perspective on Optical Imaging in Patient Care
We will explore the challenges and opportunities for direct clinical impact of innovations in microscopy and related technologies. Panelists are all practicing clinicians who routinely use imaging to directly provide patient care. In this lively and interactive live discussion, we will explore exciting and sometimes controversial topics off-the-record, including:
- artifical intelligence: hype vs true clinical game-changer
- barriers to clinical uptake of novel microscopies
- best practices to engage clinicians and patients with new technologies
- commonly missed critical factors for clinical work flow
- real world medicolegal and ethical concerns
Please send suggestions for topics or questions for the panel to eric.tkaczyk@vumc.org. Suggestions from trainees and junior colleagues are particularly encouraged.
Moderators:
Eric Tkaczyk, MD, PhD, Vanderbilt University Medical Center, USA
Milind Rajadhyaksha, PhD, Memorial Sloan Kettering Cancer Center, USA
Panelists:
Richard Levenson, MD, UC Davis Health, USA
Vic Neel, MD, PhD, Massachusetts General Hospital, USA
Harold Rabinovitz, MD, Skin and Cancer Associates - Plantation, USA
Gennady Rubinstein, MD, Dermatology & Laser Centre, USA
Eric Yang, MD, PhD, Stanford University School of Medicine, USA
Endometriosis Innovation Challenge Finalist Demonstrations
Tuesday, 26 April 09:30 – 10:00
Innovation Finalists Mária Pilar Urizar, IO-CSIC, Spain and Mahima Sharma, IIT Madras, India will present their proposals for the Endometriosis Challenge. Attendees will vote on the winner through the conference app.