Clinical and Translational Biophotonics
Events
Clinical and Translational Biophotonics
24 April 2022 – 27 April 2022 The Westin Fort Lauderdale Beach Resort, Fort Lauderdale, Florida United States
The meeting spans clinical diagnostic, surgical guidance, and therapeutic approaches that use light, with applications ranging from cancer to ophthalmology and global health. It will also include technologies for in-vivo laboratory disease research including contrast agent development and intravital microscopy in animal models.
Presented work will include reports of novel and developing technologies for clinical applications, demonstrations of clinical applications and clinical trial results, with presenters encouraged to share their experiences relating to the challenges of clinical translation. Events will include panel discussions and networking forums to develop skills and expertise for clinical translation, FDA and regulatory hurdles and fundraising.
Essential Links
Biophotonics Congress: Biomedical Optics
Topics
1. Preclinical Disease Research: Techniques and Applications
- Molecular contrast agents, probes and reporters
- Imaging methods for small animal models of cancer and other diseases
- Optical imaging of the cancer microenvironment, processes and pathways
- Targeted molecular imaging of cancer, and quantitative validation methods
- Bioluminescence techniques and applications to disease research
- Photoacoustics in disease research
- Intravital microscopy for pre-clinical disease research
2. Intravital Microscopy for Clinical Applications
- OCT techniques and applications in humans
- Endomicroscopy
- FLIM for clinical applications
- Multimodal microscopy for clinical applications
- Raman microscopy for clinical applications
- Micro-elastograpy and optical biomechanics
- Skin imaging techniques and applications
3. Clinical Spectroscopy
- Optical properties of disease
- Intravital spectroscopy for clinical applications
- Hyperspectral imaging techniques and applications in medicine
- Modeling of light propagation and optical properties
4. Intrasurgical Imaging
- Optical approaches for surgical guidance
- Intravital optical biopsy
- Perfusion evaluation
- Combined contrast agent / imaging approaches
- Dynamic contrast
- Digital staining microscopy
- Applications in neurological surgery
- Applications in cancer resection
5. Non-invasive Optical Imaging for Disease Applications
- Tomography approaches for clinical applications
- Multi-modal imaging (e.g. combined with x-ray, MRI, ultrasound)
- Photoacoustic techniques and applications in the clinic
6. Optical Therapeutics / Theranostics
- PDT, agents, techniques and applications
- Thermal ablation
- Agents for optical therapy
- Laser surgery
- Optical dosimetry
7. Clinical Translation: Biophotonics in the Clinic and Beyond
- Global health
- Applications in women’s health
- Applications in ophthalmology
- Applications in dermatology
- New contrast agents in the clinic
- Testing and evaluation of new clinical modalities
- Challenges and trajectories of clinical translation
Speakers
- Turgut Durduran, ICFO -Institut de Ciencies Fotoniques, Spain
Evaluating Endothelial and Microvascular Function in COVID-19 and Other Populations Towards Personalized Management - Viktor Gruev, Univ of Illinois at Urbana-Champaign, United States
Multispectral Bioinspired Sensors for Image Guided Surgery - Fiona Lyng, Technological University Dublin, Ireland
Raman Spectroscopy for Screening in Cervical Cancer - Active on Translation - Jenna Mueller, University of Maryland at College Park, United States
The KeySuite: Accessible Laparoscopy for Surgery in Low-Income Countries - Juergen Popp, Friedrich-Schiller-Universität Jena, Germany
Labelfree Multimodal Clinical Imaging - Gerwin Puppels, Erasmus University Medical Center, Netherlands
Translation of a Needle Based Raman Probe for Intra-operative Assessment of Margins in Oral Cancers - Jonathan Sorger, Intuitive Surgical Inc, United States
Insightful Perspective from Industry Perspective on Translation - Nicholas Stone, University of Exeter, United Kingdom
Prototypes for In-vivo Transmission Raman for Diagnosis Microcalcifications for Patients Suspected of Breast Cancer - Paola Taroni, Politecnico di Milano, Italy
SOLUS: Multimodal System Combining Ultrasounds and Diffuse Optics for Tomographic Imaging of Breast Cancer - Quanzeng Wang, Food and Drug Administration, United States
Infrared Thermographs for Measuring Elevated Body Temperature: Best Practices for Performance Evaluation
Committee
- Dan Elson, Imperial College, UK, General Chair
- James Tunnell, Univ. of Texas Austin, USA, General Chair
- Ioan Notingher, University of Nottingham, UK, Program Chair
- Jessica Ramella-Roman, Florida International University, USA, Program Chair
- Stephen Boppart, Univeristy of Illinois Urbana-Champaign, USA
- Anabela Dasilva, Fresnel Institute, France
- Auradha Godavarty, Florida International University, USA
- Michalina Gora, Wyss Center for Bio and Neuroengineering, Switzerland
- Dimitris Gorpas, HelmboltsZentrum Munich, Germany
- Zhiwei Huang, NUS, Singapore
- Xingde Li, Johns Hopkins, USA
- Igor Meglinski, Aston University, UK
- Peter Munro, UCL, UK
- Narasimhan Rajaram, University of Arkansas, USA
Plenary Session
Laura Marcu
University of California, Davis, USA
Bringing Cancer to Light in the Operating Room
This presentation concerns the development for clinically-compatible multispectral fluorescence lifetime imaging (FLIM) techniques and applications in surgical oncology. We will show FLIM’s potential for real-time intraoperative delineation of brain tumors and head-and-neck cancer during robotic surgery.
About the Speaker
Laura Marcu is Professor of Biomedical Engineering and Neurological Surgery at the University of California at Davis. She received her Ph.D. in biomedical engineering (1998) from the University of Southern California, Los Angeles. Since 2007, she has served also as co-director of the Comprehensive Cancer Center - Biomedical Technology Program at the UC Davis Medical Center. Her research interest is in the area of biomedical optics, with a particular focus on research for the development of label-free optical spectroscopy and imaging techniques for tissue diagnostics and image-guided interventions. Area of applications include surgical oncology, intravascular cardiovascular diagnostics, and regenerative medicine. She is an elected Fellow of AAAS, AIMBE, BMES, Optica, SPIE and NAI.
Wolfgang Drexler
Medical University Vienna, Austria
OCT in its 30's
After three decades, more than 75,000 publications and numerous companies being involved in its commercialization, this talk focuses on disruptive forward-looking innovations and key-technologies to further boost OCT performance enabling significantly enhanced medical diagnosis.
About the Speaker
Wolfgang Drexler, PhD, is a Professor of Medical Physics and the Head of the Center for Medical Physics and Biomedical Engineering at the Medical University of Vienna, Vienna, Austria. He spent 2 years at the Massachusetts Institute of Technology, Cambridge, MA, USA. Prior to his current position, Dr. Drexler was a Professor of Biomedical Imaging at Cardiff University, Wales, UK. Dr. Drexler’s main research area is the establishment of a novel generation of optical imaging platforms with the potential to revolutionise fundamental biological research as well as medical diagnosis. Dr. Drexler has authored >190 peer-reviewed publications and >600 conference proceedings or abstracts. He is or has previously held positions as editor or co-editor of 12 books, including 2 editions of Optical Coherence Tomography: Technology and Applications. In addition, he has given >250 invited or keynote presentations since 2000 and accomplished € 16 million research grant income since 2000.
Daniel Razansky
ETH Zürich, Switzerland
Citius, altius, fortius – boosting speed, resolution, and depth in fluorescence and optoacoustic imaging
The talk focuses on the latest additions to the arsenal of fluorescence and optoacoustic techniques to enable noninvasive deep tissue imaging of rapid biological dynamics at multiple scales, from single cells to whole organisms.
About the Speaker
Daniel Razansky is Full Professor of Biomedical Imaging with double appointment at the Faculty of Medicine, University of Zurich and the Department of Information Technologies and Electrical Engineering of ETH Zurich, where he also serves as Director of the joint Preclinical Imaging Center. He earned PhD in Biomedical Engineering (2006) and MSc in Electrical Engineering (2001) from the Technion - Israel Institute of Technology and did postdoctoral research at the Center for Molecular Imaging Research of the Harvard Medical School in Boston. Prior to moving to Zurich in 2019, he was Professor of Molecular Imaging Engineering at the Technical University of Munich and Helmholtz Center Munich. His Lab pioneered a number of imaging technologies for pre-clinical research and clinical diagnostics successfully commercialized worldwide, among them the multi-spectral optoacoustic tomography (MSOT) and hybrid optoacoustic ultrasound (OPUS). Razansky’s research has been recognized by the German Innovation Prize and multiple awards from the ERC, NIH, SNF, DFG and HFSP. He is a Founding Editor of the Photoacoustics journal and serves on Editorial Boards of a number of journals published by Springer-Nature, Elsevier, IEEE and AAPM. He is also an elected Council Member of the European Society for Molecular Imaging (ESMI), serves on the IEEE Technical Committee on Biomedical Imaging and Image Processing and has chaired numerous international conferences of the Optica (formerly OSA), WMIS, IEEE, ESMI and IFMBE. He is also an elected Fellow of the Optica (formerly OSA) and SPIE.
Anita Mahadevan-Jansen
Vanderbilt University, USA
Near infrared autofluorescence and other label free optical techniques for intraoperative guidance of endocrine surgery
In this presentation, the development of label free spectroscopy and imaging methods including near infrared autofluorescence for the identification of the parathyroid gland and evaluating its perfusion state during thyroidectomies and parathyroidectomies will be presented. We will also discuss other ways in which optical spectroscopy and imaging can help the endocrine surgeon in patient care.
About the Speaker
Anita Mahadevan-Jansen is a Professor of Biomedical Engineering and holds the Orrin H. Ingram Chair in Biomedical Engineering at Vanderbilt University. Her research considers the development of optical techniques for clinical diagnosis and surgical guidance, particularly using Raman and fluorescence spectroscopy. She serves on the Board of Directors of SPIE, and is a Fellow of SPIE, Optica, Society for Applied Spectroscopy, and the American Society for Lasers in Medicine and Surgery. She is currently serving as SPIE's President in 2022.
Special Events
Women of Biophotonics Meet & Greet
Saturday, 23 April 19:00 – 20:00
Please join Chairs Christine P. Hendon, Rainer A. Leitgeb and other members of the Biophotonics Congress committee for an informal networking event bringing together the women in biomedical optics. The program's goal is to provide an opportunity to meet other women in the field and discuss challenges and opportunities for women in biophotonics. All are welcome, regardless of gender, so please join us to meet others attending this cutting-edge conference and share your ideas on helping ensure our community and this meeting is as welcoming and inclusive as possible.
The Physicians' Perspective: A Joint MHA and Translational Session
Sunday, 24 April 13:30 – 15:30
13:30-14:00: Optical Skin Biopsy with Line-field Confocal Optical Coherence Tomography (LC-OCT), Arnaud Dubois, Damae Medical, France
14:00-15:30: Panel Discussion: Clinicians' Perspective on Optical Imaging in Patient Care
We will explore the challenges and opportunities for direct clinical impact of innovations in microscopy and related technologies. Panelists are all practicing clinicians who routinely use imaging to directly provide patient care. In this lively and interactive live discussion, we will explore exciting and sometimes controversial topics off-the-record, including:
- artifical intelligence: hype vs true clinical game-changer
- barriers to clinical uptake of novel microscopies
- best practices to engage clinicians and patients with new technologies
- commonly missed critical factors for clinical work flow
- real world medicolegal and ethical concerns
Please send suggestions for topics or questions for the panel to eric.tkaczyk@vumc.org. Suggestions from trainees and junior colleagues are particularly encouraged.
Moderators:
Eric Tkaczyk, MD, PhD, Vanderbilt University Medical Center, USA
Milind Rajadhyaksha, PhD, Memorial Sloan Kettering Cancer Center, USA
Panelists:
Richard Levenson, MD, UC Davis Health, USA
Vic Neel, MD, PhD, Massachusetts General Hospital, USA
Harold Rabinovitz, MD, Skin and Cancer Associates - Plantation, USA
Gennady Rubinstein, MD, Dermatology & Laser Centre, USA
Eric Yang, MD, PhD, Stanford University School of Medicine, USA
Endometriosis Innovation Challenge Finalist Demonstrations
Tuesday, 26 April 09:30 – 10:00
Innovation Finalists Mária Pilar Urizar, IO-CSIC, Spain and Mahima Sharma, IIT Madras, India will present their proposals for the Endometriosis Challenge. Attendees will vote on the winner through the conference app.