Optica Biophotonics Congress: Biomedical Optics

24 April 2022 – 27 April 2022 The Westin Fort Lauderdale Beach Resort, Fort Lauderdale, Florida United States

Learn how optical technologies are driving fundamental discoveries in biomedicine, enabling unprecedented resolution in biomedical imaging and leading to devices and procedures that address numerous clinical issues.

The Biophotonics Congress: Biomedical Optics focuses on technological solutions to medical challenges and medical applications. It covers diverse, cutting-edge research and innovative new tools and techniques. Its goal is to bring together an international group of leading engineers, optical and medical scientists, physicians, junior researchers and graduate students — all engaged in optical methods to advance discovery and application of medical science to clinical practice.

 

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Topics 

Clinical and Translational Biophotonics (Translational)

This topical meeting focuses on the development and application of optical techniques for clinical applications.

The meeting spans clinical diagnostic, surgical guidance, and therapeutic approaches that use light, with applications ranging from cancer to ophthalmology and global health. It will also include technologies for in-vivo laboratory disease research including contrast agent development and intravital microscopy in animal models.

Presented work will include reports of novel and developing technologies for clinical applications, demonstrations of clinical applications and clinical trial results, with presenters encouraged to share their experiences relating to the challenges of clinical translation. Events will include panel discussions and networking forums to develop skills and expertise for clinical translation, FDA and regulatory hurdles and fundraising.
 

Microscopy, Histopathology and Analytics (Microscopy)

Microscopy, Histopathology and Analytics provides a forum for presenting the latest research in tissue microscopy and computational analysis, as well as laboratory-based analytics and fluidics, along with the challenges of translating such developments into the clinic.

Example topics central to this meeting are novel forms of microscopy, computational modeling and algorithms, novel contrast agents, and clinical analytics. Example application areas are clinical diagnostics/prognostics and decision support, surgical and non-surgical therapy guidance, high-throughput drug screening, and biomarker evaluation.
 

Optical Coherence Tomography (OCT)

Focuses on new developments and applications of optical coherence tomography (OCT).

Topics central to this meeting are novel OCT light sources, imaging probes, and systems, computational modeling and imaging processing algorithms, multimodal technologies, basic and translational applications.
 

Optical Tomography and Spectroscopy (OT&S)

Focuses on new developments in non-invasive optical tomography and spectroscopy, including the fields of diffuse optical tomography (DOT) and spectroscopy (DOS), diffuse correlation tomography (DCT) and spectroscopy (DCS), photoacoustic tomography (PAT) and spectroscopy (PAS), laser speckle imaging, Raman spectroscopy, fluorescence imaging, wavefront engineering to overcome scattering, as well as on novel biophotonics developments in pre-clinical and clinical applications.

The topical will also include a specific focus on diagnostic and treatment-monitoring capabilities derived from probing tissues at the macroscopic level, as well as the development of portable and low-cost instrumentation.

Example topics central to this meeting are novel instrumentation, data analysis algorithms, pre-clinical and clinical applications highlighting the validation and applicability of novel methods and concepts. This meeting is unique in the sense that it brings together researchers working at all levels of this multidisciplinary effort and has historically provided the ecosystem feeding other more specialized areas and applicatio

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Topic Categories
 

Clinical and Translational Biophotonics 

1. Preclinical Disease Research: Techniques and Applications 

• Molecular contrast agents, probes and reporters
• Imaging methods for small animal models of cancer and other diseases
• Optical imaging of the cancer microenvironment, processes and pathways
• Targeted molecular imaging of cancer, and quantitative validation methods
• Bioluminescence techniques and applications to disease research
• Photoacoustics in disease research
• Intravital microscopy for pre-clinical disease research

2. Intravital Microscopy for Clinical Applications 

• OCT techniques and applications in humans
• Endomicroscopy
• FLIM for clinical applications
• Multimodal microscopy for clinical applications
• Raman microscopy for clinical applications
• Micro-elastograpy and optical biomechanics
• Skin imaging techniques and applications

3. Clinical Spectroscopy 

• Optical properties of disease
• Intravital spectroscopy for clinical applications
• Hyperspectral imaging techniques and applications in medicine
• Modeling of light propagation and optical properties

4. Intrasurgical Imaging 

• Optical approaches for surgical guidance
• Intravital optical biopsy
• Perfusion evaluation
• Combined contrast agent / imaging approaches
• Dynamic contrast
• Digital staining microscopy
• Applications in neurological surgery
• Applications in cancer resection

5. Non-invasive Optical Imaging for Disease Applications 

• Tomography approaches for clinical applications
• Multi-modal imaging (e.g. combined with x-ray, MRI, ultrasound)
• Photoacoustic techniques and applications in the clinic

6. Optical Therapeutics / Theranostics 

• PDT, agents, techniques and applications
• Thermal ablation
• Agents for optical therapy
• Laser surgery
• Optical dosimetry

7. Clinical Translation: Biophotonics in the Clinic and Beyond 

• Global health
• Applications in women’s health
• Applications in ophthalmology
• Applications in dermatology
• New contrast agents in the clinic
• Testing and evaluation of new clinical modalities
• Challenges and trajectories of clinical translation

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Speakers

Laura Marcu

University of California, Davis, USA

Laura Marcu is Professor of Biomedical Engineering and Neurological Surgery at the University of California at Davis. She received her Ph.D. in biomedical engineering (1998) from the University of Southern California, Los Angeles. Since 2007, she has served also as co-director of the Comprehensive Cancer Center - Biomedical Technology Program at the UC Davis Medical Center. Her research interest is in the area of biomedical optics, with a particular focus on research for the development of label-free optical spectroscopy and imaging techniques for tissue diagnostics and image-guided interventions. Area of applications include surgical oncology, intravascular cardiovascular diagnostics, and regenerative medicine. She is an elected Fellow of AAAS, AIMBE, BMES, Optica, SPIE and NAI.

Wolfgang Drexler

Medical University Vienna, Austria

Wolfgang Drexler, PhD, is a Professor of Medical Physics and the Head of the Center for Medical Physics and Biomedical Engineering at the Medical University of Vienna, Vienna, Austria. He spent 2 years at the Massachusetts Institute of Technology, Cambridge, MA, USA. Prior to his current position, Dr. Drexler was a Professor of Biomedical Imaging at Cardiff University, Wales, UK. Dr. Drexler’s main research area is the establishment of a novel generation of optical imaging platforms with the potential to revolutionise fundamental biological research as well as medical diagnosis. Dr. Drexler has authored >190 peer-reviewed publications and >600 conference proceedings or abstracts. He is or has previously held positions as editor or co-editor of 12 books, including 2 editions of Optical Coherence Tomography: Technology and Applications. In addition, he has given >250 invited or keynote presentations since 2000 and accomplished € 16 million research grant income since 2000.

Daniel Razansky

ETH Zürich, Switzerland

Daniel Razansky is Full Professor of Biomedical Imaging with double appointment at the Faculty of Medicine, University of Zurich and the Department of Information Technologies and Electrical Engineering of ETH Zurich, where he also serves as Director of the joint Preclinical Imaging Center. He earned PhD in Biomedical Engineering (2006) and MSc in Electrical Engineering (2001) from the Technion - Israel Institute of Technology and did postdoctoral research at the Center for Molecular Imaging Research of the Harvard Medical School in Boston. Prior to moving to Zurich in 2019, he was Professor of Molecular Imaging Engineering at the Technical University of Munich and Helmholtz Center Munich. His Lab pioneered a number of imaging technologies for pre-​clinical research and clinical diagnostics successfully commercialized worldwide, among them the multi-​spectral optoacoustic tomography (MSOT) and hybrid optoacoustic ultrasound (OPUS). Razansky’s research has been recognized by the German Innovation Prize and multiple awards from the ERC, NIH, SNF, DFG and HFSP. He is a Founding Editor of the Photoacoustics journal and serves on Editorial Boards of a number of journals published by Springer-​Nature, Elsevier, IEEE and AAPM. He is also an elected Council Member of the European Society for Molecular Imaging (ESMI), serves on the IEEE Technical Committee on Biomedical Imaging and Image Processing and has chaired numerous international conferences of the Optica (formerly OSA), WMIS, IEEE, ESMI and IFMBE. He is also an elected Fellow of the Optica (formerly OSA) and SPIE.

Anita Mahadevan-Jansen

Vanderbilt University, USA

Anita Mahadevan-Jansen is a Professor of Biomedical Engineering and holds the Orrin H. Ingram Chair in Biomedical Engineering at Vanderbilt University. Her research considers the development of optical techniques for clinical diagnosis and surgical guidance, particularly using Raman and fluorescence spectroscopy. She serves on the Board of Directors of SPIE, and is a Fellow of SPIE, Optica, Society for Applied Spectroscopy, and the American Society for Lasers in Medicine and Surgery. She is currently serving as SPIE's President in 2022.

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Invited Speakers
 

Clinical and Translational Biophotonics

• Turgut Durduran, ICFO -Institut de Ciencies Fotoniques, Spain
  Evaluating Endothelial and Microvascular Function in COVID-19 and Other Populations Towards Personalized Management
• Viktor Gruev, Univ of Illinois at Urbana-Champaign, United States
  Multispectral Bioinspired Sensors for Image Guided Surgery
• Fiona Lyng, Technological University Dublin, Ireland
  Raman Spectroscopy for Screening in Cervical Cancer - Active on Translation
• Jenna Mueller, University of Maryland at College Park, United States
  The KeySuite: Accessible Laparoscopy for Surgery in Low-Income Countries
• Juergen Popp, Friedrich-Schiller-Universität Jena, Germany
  Labelfree Multimodal Clinical Imaging
• Gerwin Puppels, Erasmus University Medical Center, Netherlands
  Translation of a Needle Based Raman Probe for Intra-operative Assessment of Margins in Oral Cancers
• Jonathan Sorger, Intuitive Surgical Inc, United States
  Insightful Perspective from Industry Perspective on Translation
• Nicholas Stone, University of Exeter, United Kingdom
  Prototypes for In-vivo Transmission Raman for Diagnosis Microcalcifications for Patients Suspected of Breast Cancer
• Paola Taroni, Politecnico di Milano, Italy
  SOLUS: Multimodal System Combining Ultrasounds and Diffuse Optics for Tomographic Imaging of Breast Cancer
• Quanzeng Wang, Food and Drug Administration, United States
  Infrared Thermographs for Measuring Elevated Body Temperature: Best Practices for Performance Evaluation
   

Microscopy Histopathology and Analytics

• Mihaela Balu, UC Irvine Beckman Laser Institute, United States
  Fast, Large Area Multiphoton Exoscope (FLAME) for Clinical Skin Imaging
   
• Margarida Barroso, Albany Medical College, United States
  The Role of 3D Cancer Cell Growth in Organelle Morphology, Topology and Function
   
• Arnaud Dubois, Institut d'Optique Graduate School, France
  Optical Skin Biopsy with Line-field Confocal Optical Coherence Tomography (LC-OCT)
   
• Nicholas Durr, Johns Hopkins University, United States
  Non-invasive Blood Analysis with Deep Learning and Oblique Back-illumination Microscopy
   
• Roarke Horstmeyer, Duke University, United States
  Parallelized Microscopy for Teravoxel Whole-slide Imaging
   
• Jennifer Hunter, University of Rochester, Canada
  Adaptive Optics Two-photon Excited Fluorescence Lifetime Ophthalmosopy
   
• Michael Jenkins, Case Western Reserve University, United States
  New Methods and Tools for 3D Microscopy
   
• Lija Joseph, Lowell General Hospital, United States
  Cytological Detection of Thyroid Cancer
   
• DongKyun Kang, University of Arizona, United States
  Low-cost, In Vivo Confocal Microscopy
   
• Muyinatu Lediju Bell, Johns Hopkins University, United States
  Laser Safety for Photoacoustic-guided Surgery
   
• Faisal Mahmood, Harvard University, United States
  Data-efficient and Multimodal Computational Pathology
   
• Shachi Mittal, University of Washington, United States
  Digital and Molecular Profiling of Breast Cancer
   
• Chetan Patil, Temple University, United States
  Monte-Carlo-based Simulations of Sources of Bias in Clinical Measurements
   
• Nicholas Reder, Lightspeed Microscopy, United States
  3D Pathology with AI for Improved Drug Development and Clinical Diagnostics
   
• Zachary Smith, Univ of Science and Technology of China, China
  Enabling Cost-effective, Precise Blood Analysis Through Illumination and Pupil Engineering
   
• Martin Villiger, Wellman Center for Photomedicine, United States
  Catheter-based Optical Coherence Polarimetry for Guiding Interventions
   

Optical Coherence Tomography

• Jennifer Barton, University of Arizona, United States
  OCT and Multispectral Imaging of the Human Fallopian Tube
   
• Lukas Glandorf, Universität Zürich, Switzerland
  Computational Aberration Correction Enhances Field-of-View in Visible-Light Optical Coherence Microscopy
   
• Kate Grieve, Centre Hospitalier National d'Ophtalmolo, France
  Advances in Time Domain Full Field OCT for Ophthalmology
   
• Gereon Hüttmann, Medizinisches Laserzentrum Lubeck GmbH, Germany
  Dynamic Contrast in Optical Coherence Tomography (OCT) Imaging
   
• Xingde Li, Johns Hopkins University, United States
  Multi-functional OCT Endoscopy
   
• Susana Marcos, University of Rochester, United States
  Anterior Segment Optical Coherence (OCT) Tomography: From Images to Quantitative Diagnostics
   
• Alice Motschi, Medical University of Vienna, Austria
  Large Field of View Depolarization Mapping in the Human Retina Using Polarization-Sensitive OCT
   
• Ryan Sentosa, Medical University of Vienna, Austria
  Multimodal Optical Coherence Tomography, Raman Spectroscopy and IR Fundus Imaging for In Vivo Retinal Imaging
   
• Vivek Srinivasan, University of California Davis, United States
  Micron-Scale Visible Light OCT of the Retina: The Search for New Bands
   
• Shang Wang, Stevens Institute of Technology, United States
  OCT Imaging of Oocyte and Embryo Transport in Mouse Oviduct In Vivo
   
• Piotr Wegrzyn, Uniwersytet Warszawski, Poland
  Role of Multimode Fibers in Structural Imaging of the Choroidal and Retinal Tissue with Spatio-Temporal Optical Coherence Tomography (STOC-T)
   
• Vladimir Zaitsev, Russian Academy of Sciences, Russia
  Recent Advances in OCT-based Strain Mapping and Compression OCE
   
• Chao Zhou, Washington University in St Louis, United States
  High-resolution OCT Imaging and Optogenetic Pacing in Drosophila and 3D Organoids
   
• Fernando Zvietcovich, University of Houston, Spain
  In-vivo Assessment of Corneal Biomechanics Under Localized Cross-linking Treatment Using Wave-based Optical Coherence Elastography
   

Optical Tomography and Spectroscopy

• Audrey Bowden, Vanderbilt University, United States
  User-centric Hardware and Software Development for Low-cost Naturalistic Neuroimaging Using fNIRS
   
• Sabrina Brigadoi, Università degli Studi di Padova, Italy
  The BabyGlucoLight Project: Understanding the Impact of Neonatal Glycemic Control on Brain Hemodynamics and Developmental Outcome in Very Preterm Neonates
   
• Mamadou Diop, Lawson Health Research Institute, Canada
  Hyperspectral Time-Resolved Near Infrared Spectroscopy
   
• James Guggenheim, University of Birmingham, United Kingdom
  Enhancing Photoacoustic Imaging with Wavefront Shaping and Optical Ultrasound Sensors
   
• Puxiang Lai, Hong Kong Polytechnic University, Hong Kong
  Photoacoustic Tomography and Wavefront Shaping: High-resolution Optical Imaging and Focusing at Depths in Biological Tissue
   
• Chris McKnight, University of St Andrews, United Kingdom
  Near-infrared Spectroscopy on Animals
   
• David Miller, Dynamic Light Inc, United States
  Laser Speckle Contrast Imaging for Intraoperative Blood Flow Visualization During Neurosurgery
   
• Sara Mosca, UKRI Research England, United Kingdom
  Spatially Offset Raman Spectroscopy for Estimating the Depth of Inclusion in Diffusely Scattering Samples
   
• Thao Pham, Boston University, United States
  Depth-Resolved Frequency-Domain Diffuse Optical Augmented Reality for Breast Cancer Monitoring
   
• Shy Shoham, New York University, United States
  Optoacoustic Imaging of the Brain
   
• Graham Spicer, University of Cambridge, United Kingdom
  Spectral Endoscopy Enhances Contrast for Cancer Detection
   
• Tanja Tarvainen, Itä-Suomen Yliopisto, Finland
  Modelling and Inverse Problem in Diffuse Optical Tomography and Quantitative Photoacoustic Tomography
   
• Liangzhong Xiang, University of California Irvine, United States
  X-ray Induced Acoustic Computed Tomography (XACT)
   

Optics and the Brain

• Osnath Assayag, 3i Group France, France
  SLM-based 3D Photostimulation and Temporal Focusing : A Commercial Approach
   
• Adam Eggebrecht, Washington University in St Louis, United States
  Towards Illuminating Brain Function in Critical Care Settings with High Density Diffuse Optical Tomography
   
• Ali Ertürk, Helmholtz Zentrum München GmbH, Germany
  IDISCO w/Proteomics
   
• Xue Han, Boston University, United States
  Large-scale and High-speed Voltage Imaging Analysis of Biological Neural Networks During Behavior
   
• Na Ji, University of California Berkeley, United States
  Engineering Bessel Beam for High-Resolution Brain Imaging
   
• Adam Liebert, Inst Biocybernet i Inżynierii Biomed PAN, Poland
  Time-Resolved Approach for Enhancement of NIRS And DCS Sensitivity to Changes in Cerebral Blood Flow and Oxygenation
   
• Ashwin Parthasarathy, University of South Florida, United States
  Low-cost Approaches for Quantitative Optical Measurement of Cerebral Blood Flow
   
• Nicolas Pégard, Univ of North Carolina at Chapel Hill, United States
  Fast and Efficient Computer-generated Holography Techniques for Optogenetic Control of Cell Ensembles
   
• Mitchell Robinson, Athinoula A. Martinos Center, United States
  Improving Depth Sensitivity and Brain Blood Flow Specificity of Diffuse Correlation Spectroscopy
   
• Daniel Scarbrough, Colorado School of Mines, United States
  Advances in Multimodal, Single Element Detection Spatial Frequency Modulation Imaging
   
• Ilias Tachtsidis, University College London, United Kingdom
  Metabolic Neuromonitoring with Optics: Systems and Applications
   
• Lei Tian, Boston University, United States
  Computational Miniature Mesoscope for Large-Scale Fluorescence Imaging
   
• Alipasha Vaziri, Rockefeller University, United States
  Towards Cortex-wide Recording of Neuroactivity at Cellular Resolution
   
• Haining Zhong, OHSU Vollum Institute, United States
  In Vivo Imaging of Intracellular Signaling Underlying Neuromodulation

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Plenary Sessions
 

Bringing Cancer to Light in the Operating Room

This presentation concerns the development for clinically-compatible multispectral fluorescence lifetime imaging (FLIM) techniques and applications in surgical oncology. We will show FLIM’s potential for real-time intraoperative delineation of brain tumors and head-and-neck cancer during robotic surgery.

OCT in its 30's

After three decades, more than 75,000 publications and numerous companies being involved in its commercialization, this talk focuses on disruptive forward-looking innovations and key-technologies to further boost OCT performance enabling significantly enhanced medical diagnosis.

Citius, altius, fortius – boosting speed, resolution, and depth in fluorescence and optoacoustic imaging

The talk focuses on the latest additions to the arsenal of fluorescence and optoacoustic techniques to enable noninvasive deep tissue imaging of rapid biological dynamics at multiple scales, from single cells to whole organisms.

Near infrared autofluorescence and other label free optical techniques for intraoperative guidance of endocrine surgery

 In this presentation, the development of label free spectroscopy and imaging methods including near infrared autofluorescence for the identification of the parathyroid gland and evaluating its perfusion state during thyroidectomies and parathyroidectomies will be presented. We will also discuss other ways in which optical spectroscopy and imaging can help the endocrine surgeon in patient care.  

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