Fluorescent-proteins: New generation of sensing qubits?

Optica Distinguished Lecture Series on Quantum Science and Technology

We demonstrate an optically addressable protein-based spin qubit encoded in the metastable triplet state of fluorescent protein. Our protein-qubit has coherence times rivaling NV centers in nanodiamonds but are roughly 10-times smaller and genetically encodable.

About the Speaker

Peter Maurer is an assistant professor at the University of Chicago. His research focuses on advancing quantum sensing techniques to probe the physical properties of biological processes with nanoscale resolution. Prior to joining the University of Chicago Peter completed his PhD training with Mikhail Lukin at Harvard and Steven Chu at Stanford.

Enhancing Fluorescence Guided Surgery with Nanobodies and Fluorescence Lifetime Imaging

This presentation explores enhancing fluorescence-guided surgery with Nanobodies — targeted agents offering rapid pharmacokinetics and tumor specificity — and demonstrates how fluorescence lifetime imaging adds biological insights and reduces non-specific signals compared to conventional fluorescence methods.

About the Speaker

Sophie Hernot, a bioengineer with a PhD in Medical Sciences, is a leading professor in the Molecular Imaging and Therapy research group at Vrije Universiteit Brussel, Belgium. Her research centers on developing, preclinically validating and clinically translating fluorescent and radiolabeled Nanobody-based tracers for image-guided applications. As the academic director of the In vivo Cellular and Molecular Imaging Core Facility, she also promotes the adoption of innovative imaging techniques across diverse research fields, enhancing in vivo understanding of biological processes.

Pushing the Limits of Microscopy

No matter how good microscopes have become, there will always be a need for them to be better. I will describe various strategies to push the limits of microscopes for life science applications.

About the Speaker

Jerome Mertz received an AB in physics from Princeton University and a PhD in quantum optics from UC Santa Barbara and the University of Paris VI. Following postdoctoral studies at the University of Konstanz and at Cornell University, he became a CNRS research director at the Ecole Supérieure de Physique et de Chimie Industrielle in Paris. He is currently a professor of Biomedical Engineering at Boston University. His interests are in the development and applications of novel optical microscopy techniques for biological imaging. He is also author of a textbook titled Introduction to Optical Microscopy, 2nd Ed.

Maximizing the Impact of Biomedical Imaging and Microscopy

Optical methods are uniquely suited to mapping molecular and functional information across scales. From diffuse-imaging to super-resolution microscopy, how can we ensure that our work will lead to scientific breakthroughs and improvements in patient care?

About the Speaker

Dr. Elizabeth M.C. Hillman’s laboratory develops diverse optical imaging and microscopy techniques and applies them to studying the structure and function of the brain and other living tissues. She completed undergraduate and PhD training in Physics and Medical Physics at University College London. After post-doctoral work at Massachusetts General Hospital, she joined the faculty at Columbia University in 2006, where she is the Herbert and Florence Irving Professor in the Zuckerman Mind Brain Behavior Institute, and the Departments of Biomedical Engineering and Radiology.